Novel N-3 Substituted TSAO-T Derivatives: Synthesis and Anti-HIV-Evaluation.
Novel derivatives of the anti-HIV-1 agent, TSAO-T, bearing at the N-3 position alkylating groups or photoaffinity labels were prepared and evaluated for their anti-HIV activity. All of these compounds demonstrated pronounced anti-HIV-1 activity and inhibited HIV-1 RT; however, we were unable to detect stable covalent […]
Diastereomer separation of azobenzene-tethered oligodeoxyribonucleotides and determination of their absolute configurations by enzymatic digestion.
Two diastereomers were produced by the introduction of azobenzene-tethering prochiral linker (2,2-bis(hydroxymethyl)propionic acid) in the modified ODN, which had been used for the photoregulation of DNA functions. We found that this modified ODN with sequence 5\’-…pNpXpN…-3\’ (p = phosphate; […]
Acyclic Phosphonate Nucleotides and Human Adenylate Kinases: Impact of a Borano Group on alpha-P Position.
Adenylate kinases are involved in the activation of antiviral drugs such as the acyclic phosphonates analogs PMEA and (R)PMPA. We examine the in vitro phosphorylation of PMEA and PMPA bearing a borano- or a H- group on the […]
Role of hypaphorine in the toxicity of Astragalus lusitanicus.
Hypaphorine, an alpha-N,N,N-trimethyltryptophan betaine, was isolated, for the first time, from Astragalus lusitanicus Lam. (Fabaceae), a plant highly toxic for lambs and goats. This alkaloid was characterized by NMR and MS analysis. Hypaphorine was previously reported to be a convulsive poison. To confirm the […]
Effect of ethyl acetate extract from Marchantia convoluta on inhibition of human liver carcinoma HepG2 cells.
The effect of the dichloromethane fraction (DF) of the ethyl acetate extract from Marchantia convoluta on the inhibition of human liver carcinoma cell line HepG2 was investigated. DF can remarkably induce HepG2 cell apoptotic, accompanied by a […]
A new 3-arylcoumarin from the roots of an Egyptian collection of Lotus polyphyllos.
Further investigation of different fractions from Lotus polyphyllos Clarke roots resulted in the isolation of the new 3-arylcoumarin derivative; 4\’,6\’-dihydroxy-7, 2\’-dimethoxy-3-arylcoumarin (5). In addition, the known compounds beta-sitosterol, 1-hexacosanol (1), n-tetracosyl p-coumarate (2), 4\’-O-methylderrone (4), and quercetin (6) were identified. […]
Isolation and structure determination of the cembranoid eunicin from a new genus of octocoral, Pseudoplexaura.
The known cembranoid diterpene eunicin (1) was isolated from a new genus of octocoral, Pseudoplexaura, collected in the Caribbean. The complete assignment of the (13)C and (1)H NMR spectra, including differentiation of pro-R and pro-S hydrogens and elucidation […]
Phytotherapeutic inhibition of supragingival dental plaque.
Antimicrobial activities and biofilm-formation preventive properties of Mentha piperita and Cuminum cyminum essential oils and chlorhexidine were assessed against Streptococcus mutans and Streptococcus pyogenes. Gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS) analysis led to the identification of 26 and 32 compounds in the essential oils of […]
An experimental study of the effects of Matricaria chamomilla extract on cutaneous burn wound healing in albino rats.
Previous studies conducted on the anti-inflammatory, antimicrobial and antioxidant effects of Matricaria chamomilla (chamomile) extract led us to study the effect of topical chamomile extract on burn wound healing in albino rats. Thirty male albino […]
Isolation of beta-glucan from the cell wall of Saccharomyces cerevisiae.
beta-Glucan, one of the major cell wall components of Saccharomyces cerevisiae (S. cerevisiae), has been found to enhance immune functions. At present study, we developed an optimal procedure to extract and purify beta-glucan. At first, yeast cells were grown in sabouraud dextrose agar […]
