Medical Library

Computational studies of Fe(III) binding to bryostatins, bryostatin analogs, siderophores and marine natural products: arguments for ferric complexes in medicinal applications.
In this computational study, geometric factors are calculated by applying semi-empirical methods (PM3) that support experimental evidence from this lab where bryostatins can bind trivalent iron with six Fe-O bonds forming an […]

Composition and antimicrobial activity of the essential oil of Acronychia pedunculata (L.) Miq. from Vietnam.
The chemical composition and the antimicrobial activity of the essential oil isolated from aerial parts of Acronychia pedunculata (L.) Miq. from Vietnam are reported. Analysis was carried out by GC (RI), GC-MS and (13)C NMR. Thirty-four compounds were […]

Synthesis and structure-activity relationship study of monotesone-A, an antifungal component of Monotes engleri.
The synthesis of (+/-)-monotesone-A, an antifungal component of Monotes engleri, as well as its four structural analogues were accomplished starting from the corresponding MOM-protected phloracetophenone and benzaldehyde derivatives. Antifungal activities of the five flavanone derivatives were studied against Candida albicans […]

A new benzofuranic acid from the leaves of Rhus alata.
From leaves of Rhus alata, one new benzofuranic acid named [(2E)-3-(4-hydroxy-5,7-dimethyl- benzo[3,4-b] furan-6-yloxy)-prop-2-enoic acid has been isolated together with eight known compounds: dimethyl ester of terephthalic acid, beta-amyrin, friedelin, lupeol, beta-sitosterol, oleanolic acid, taraxerone and ethyl gallate. Structural elucidations were done on the […]

Disseminated fungal infection in a renal transplant recipient involving Macrophomina phaseolina and Scytalidium dimidiatum: case report and review of taxonomic changes among medically important members of the Botryosphaeriaceae.
We report the first case of human infection with the fungal plant pathogen Macrophomina phaseolina in a Sri Lankan-born Canadian man following a renal transplant […]

Disseminated cryptococcosis with necrotizing fasciitis in an apparently immunocompetent host: a case report.
We present an unusual case of disseminated cryptococcosis with necrotizing fascitis in an immunocompetent host. The multi-system cryptococcal infection was proved using standard microbiological, histopathological and radiological investigations. After a combination of antifungal, antimicrobial and surgical therapy clinical cure was […]

Cholesterol dependent and Amphotericin B resistant isolates of a Candida glabrata strain from an Intensive Care Unit patient.
Here we report on two isolates of Candida glabrata recovered from urine samples collected from of an Intensive Care Unit patient. D1/D2 and ITS 1+2 rDNA sequence analysis confirmed its identification. The isolates were cholesterol […]

Candida albicans metabolite affects the cytoskeleton and phagocytic activity of murine macrophages.
Candida albicans is the most common opportunistic fungal pathogen of humans, causing systemic disease in immunocompromised patients. Host resistance to C. albicans infections is mediated predominantly by neutrophils and monocytes/macrophages. We have previously shown that exposure of a human epithelial cell […]

Human neutrophils susceptibility to Paracoccidioides brasiliensis: an ultrastructural and cytochemical assay.
Paracoccidioidomycosis, caused by the dimorphic fungus Paracoccidioides brasiliensis, is the most prevalent systemic mycosis of Latin America, with Brazil accounting for 80% of the reported cases. The great number of neutrophils found in P. brasiliensis granulomas demonstrates the importance of polymorphonuclear neutrophils […]

Characterization of caspofungin susceptibilities by broth and agar in Candida albicans clinical isolates with characterized mechanisms of azole resistance.
Caspofungin (CSP) susceptibilities of Candida albicans, as determined by broth microdilution methods, have not been found to be related to azole susceptibilities or resistance. In contrast, it has been observed that azole-resistant clinical isolates […]