Technical note: A rapid diagnostic test detects plague in ancient human remains: An example of the interaction between archeological and biological approaches (southeastern France, 16th-18th centuries).
A rapid diagnostic test (RDT) that detects Yersinia pestis F1 antigen was applied to 28 putative plague victims exhumed from seven burial sites in southeastern France dating […]
Cerebral vasculopathy does not equal primary central nervous system vasculitis.
Elkind MS, Wright C.
Department of Neurology, Columbia University, New York, NY.
Cell-specific alterations of glutamate receptor expression in tuberous sclerosis complex cortical tubers.
OBJECTIVE: Genetic loss of TSC1/TSC2 function in tuberous sclerosis complex (TSC) results in overactivation of the mammalian target of rapamycin complex 1 pathway, leading to cellular dysplasia. We hypothesized that the dysplastic cells in TSC tubers are heterogeneous, including separable classes […]
Evidence-based medicine vs medicine-based evidence.
Sethi NK, Sethi PK.
Department of Neurology, New York Presbyterianâ€Weill Cornell Medical Center, New York, NY.
Lag effect of particulate air pollution on lung function in children.
We assessed the relationship between particle air pollution and changes in lung function in children as measured by spirometry over time. Data were collected from air pollution and family health examinations of 181 subjects, aged 9-19 years, in a Korean community. The […]
Placebo response to caffeine improves reaction time performance in sleepy people.
Caffeine is the most widely used stimulant to counteract sleepiness. However, little is known about any placebo effect of caffeine in sleepy people and the effect of suggestibility. Over a 95 min test period, and in a counterbalanced design, 16 young healthy […]
Biophysics meets membrane-active peptides.
Castanho MA, Dathe M.
Dark proteins: Effect of inclusion body formation on quantification of protein expression.
Plasmid-borne gene expression systems have found wide application in the emerging fields of systems biology and synthetic biology, where plasmids are used to implement simple network architectures, either to test systems biology hypotheses about issues such as gene expression noise or […]
Crystal structure of native O-acetyl-serine sulfhydrylase from Entamoeba histolytica and its complex with cysteine: Structural evidence for cysteine binding and lack of interactions with serine acetyl transferase.
Cysteine plays a major role in the antioxidative defense mechanisms of the human parasite Entameoba histolytica. The major route of cysteine biosynthesis in this parasite is […]
SPARC-induced increase in glioma matrix and decrease in vascularity are associated with reduced VEGF expression and secretion.
Glioblastomas are heterogeneous tumors displaying regions of necrosis, proliferation, angiogenesis, apoptosis and invasion. SPARC, a matricellular protein that negatively regulates angiogenesis and cell proliferation, but enhances cell deadhesion from matrix, is upregulated in gliomas (Grades II-IV). […]
