Medical Library

Further evidence for association of the RGS2 gene with antipsychotic-induced parkinsonism: protective role of a functional polymorphism in the 3\’-untranslated region.
RGS2 (regulator of G-protein signaling 2) modulates dopamine receptor signal transduction. Functional variants in the gene may influence susceptibility to extrapyramidal symptoms (EPS) induced by antipsychotic drugs. To further investigate our previous […]

Dendritic cells: driving the differentiation programme of T cells in viral infections.
Protective immunity against viral pathogens depends on the generation and maintenance of a small population of memory CD8(+) T cells. Successful memory cell generation begins with early interactions between naïve T cell and dendritic cells (DCs) within the inflammatory milieu of […]

Non-invasive assessment of lower extremity muscle composition after incomplete spinal cord injury.
Study Design: Cross-sectional study.Objective: (1) To quantify intramyocellular lipid (IMCL) content of the soleus muscle. (2) To assess the T(2) relaxation rates in the lower extremity skeletal muscles in persons with incomplete spinal cord injury (SCI).Setting: Academic Institution, Florida.Methods: Eight subjects […]

Can cell therapy heal a spinal cord injury?
Study design:Literature survey.Objectives:To summarize and discuss current possibilities and success rates for the treatment of spinal cord injury in animal models.Settings:University of Antwerp, Belgium.Methods:We searched Pubmed for publications from 1997 onwards. Seven older papers were used for completion of data.Results:Despite major progress in pharmacological and […]

The use of tracheal stoma stents in high spinal cord injury: a patient-friendly alternative to long-term tracheostomy tubes.
Study design:Case series.Setting:North West Regional Spinal Injuries Unit, Southport and Formby District General Hospital, UK.Objectives:To identify a novel type of tracheal stents for use in patients with high spinal cord injury. Patients with high spinal […]

Obesity treatment and cardiovascular prevention in mentally retarded subjects.
Zoppo A, Asteria C.
1Department of Experimental Endocrinology and Cardiovascular Prevention, IRCCS MultiMedica, Sesto San Giovanni, Milan, Italy.

Infection-induced inflammatory response of adipocytes in vitro.
Background:Abdominal obesity plays an important role in the development of insulin resistance, diabetes mellitus and atherosclerosis. The exact pathophysiological mechanisms are unclear but adipocyte dysfunction is thought to be crucial. Infections are associated with the development of atherosclerosis as well as diabetes. In this study we […]

Sleep patterns and television viewing in relation to obesity and blood pressure: evidence from an adolescent Brazilian birth cohort.
Background:Disruption of circadian rhythms has been associated with obesity in children and adolescents, and with hypertension in adults, in industrialized populations.Objective:We examined cross-sectional associations between sleep duration or television viewing and obesity and blood […]

Genomewide association for schizophrenia in the CATIE study: results of stage 1.
Little is known for certain about the genetics of schizophrenia. The advent of genomewide association has been widely anticipated as a promising means to identify reproducible DNA sequence variation associated with this important and debilitating disorder. A total of 738 cases […]

Glutamate as a spectroscopic marker of hippocampal structural plasticity is elevated in long-term euthymic bipolar patients on chronic lithium therapy and correlates inversely with diurnal cortisol.
While an excess of glucocorticoids is associated with hippocampal pathology in mood disorders, lithium exerts robust neuroprotective and neurotrophic effects. Here, 21 stably remitted bipolar I patients […]