Medical Library

Erythropoietin ameliorates chemotherapy-induced fibrosis of the lungs in a preclinical murine model.
Organ toxicity induced by chemotherapeutic drugs is a serious obstacle in the effective treatment of patients suffering from cancer and autoimmune disease. A strong association exists between pulmonary toxicity, particularly fibrosis, and chemotherapeutic drugs. Attempts have been made to identify compounds […]

Next-day cognition, psychomotor function, and driving-related skills following nighttime administration of eszopiclone.
OBJECTIVE: To evaluate next-day driving ability, as assessed by brake reaction time (BRT), and cognitive/psychomotor function following nighttime administration of 3 mg eszopiclone. METHODS: Two randomized, double-blind, placebo-controlled, cross-over studies were performed in healthy volunteers (n = 32) and patients with […]

Spotlight.
Kirchweger G.

Erratum: MRI monitoring of focal cerebral ischemia in peroxisome proliferator-activated receptor (PPAR)-deficient mice.
NMR In Biomedicine: MRI monitoring of focal cerebral ischemia in peroxisome proliferator-activated receptor (PPAR)-deficient mice. Jean-Baptiste Pialat, Tae-Hee Chao, Olivier Beuf, Elisabeth Joye, Samir Moucharaffie, Jean-Baptiste Langlois, Chantal Nemoz, Marc Janier, Yves Berthezene, Norbert Nighoghossian, Béatrice Desvergnre and Marlene Wiart. […]

Erratum: Effects of AZD2171 and vandetanib (ZD6474, Zactima) on haemodynamic variables in an SW620 human colon tumour model: an investigation using dynamic contrast-enhanced MRI and the rapid clearance blood pool contrast agent, P792 (gadomelitol).
Bradley DP, Tessier JL, Checkley D, Kuribayashi H, Waterton JC, Kendrew J, Wedge SR.
Department of Enabling Capabilities and […]

Investigation of volatile biomarkers in liver cancer blood using solid-phase microextraction and gas chromatography/mass spectrometry.
Solid-phase microextraction (SPME) followed by gas chromatography/mass spectrometry (GC/MS) was used for the detection of liver cancer volatile biomarkers. Headspace SPME conditions (fiber coating, extraction temperature and extraction time) and desorption conditions were optimized and applied to the […]

A new rapid micro-method for the molecular-chemical characterization of rhizodeposits by field-ionization mass spectrometry.
Time-consuming investigation of rhizodeposit composition by leaching, freeze-drying of leachate, and pyrolysis-field ionization mass spectrometry (Py-FIMS) of solid samples was replaced by direct Py-FIMS of a 5 microL liquid rhizodeposit sample which was evaporated overnight in the quartz tube […]

PeakSelect: preprocessing tandem mass spectra for better peptide identification.
We present a new preprocessing method, PeakSelect, to improve the accuracy and efficiency of Tandem Mass-Spec peptide (protein) identification. The fundamental difference between noise and fragment ions in spectra is that ions have isotopes but noise does not. We propose a new and important […]

Preview: Chem. Eur. J. 11/2008.

Pharmacokinetics of dihydroartemisinin in Artekin tablets for single and repeated dosing in Chinese healthy volunteers.
Aim. To study the pharmacokinetics of dihydroartemisinin (DHA) in Artekin (compound dihydroartemisinin) tablets in Chinese healthy volunteers. Methods. Eighteen healthy volunteers (9 males, 9 females) received Artekin tablets for oral administration. The plasma samples of DHA were analysed […]