Harnessing the RNA interference pathway to advance treatment and prevention of hepatocellular carcinoma.
Primary liver cancer is the fifth most common malignancy in the world and is a leading cause of cancer-related mortality. Available treatment for hepatocellular carcinoma (HCC), the commonest primary liver cancer, is rarely curative and there is a need to […]
Radioembolization for the treatment of unresectable hepatocellular carcinoma: A clinical review.
Hepatocellular carcinoma (HCC) is the sixth most common cancer in the world. The majority of patients with HCC present with unresectable disease. These patients have historically had limited treatment options secondary to HCC demonstrating chemoresistance to the currently available systemic therapies. Additionally, […]
Natural history of hepatitis-related hepatocellular carcinoma.
Hepatocellular carcinoma (HCC) is an important cause of cancer death in the world. It has great regional differences in the pathology and epidemiology. The variation is greatly influenced by the aetiologies of the disease. Hepatitis B and C infection are the most important risk factors. HCC incidence […]
Hepatocellular carcinoma, human immunodeficiency virus and viral hepatitis in the HAART era.
The incidence of hepatocellular carcinoma (HCC) in patients with human immunodeficiency virus (HIV) is rising. HCC in HIV almost invariably occurs in the context of hepatitis C virus (HCV) or hepatitis B virus (HBV) co-infection and, on account of shared modes […]
Gastric cancer: Animal studies on the risk of hypoacidity and hypergastrinemia.
Gastric hypoacidity and hypergastrinaemia are seen in several conditions associated with an increased risk of gastric malignancy. Hypoacidity and hypergastrinaemia are closely related and their long-term effects are difficult to study separately in patients. Studies using animal models can provide valuable information […]
Complications of collagenous colitis.
Microscopic forms of colitis have been described, including collagenous colitis. This disorder generally has an apparently benign clinical course. However, a number of gastric and intestinal complications, possibly coincidental, may develop with collagenous colitis. Distinctive inflammatory disorders of the gastric mucosa have been described, including lymphocytic gastritis and collagenous […]
Enhancement of biogenic sulfide production in a packed-bed bioreactor via critical inoculum design and carrier material selection.
Sulfate reducing bacteria (SRB) are commonly used in environmental bioprocesses for the treatment of acid mine drainage and sulfate wastewaters. Biogenic H(2)S is also a potential source of H(2) fuel with the recent development of H(2)S […]
Novel therapeutic approaches for hepatocellulcar carcinoma: Fact and fiction.
Hepatocellular carcinoma (HCC) is the most common primary liver cancer and accounts for 80%-90% of this class of malignancy. So far, understanding of its pathogenesis and effective therapeutic methods are rather limited. In this issue, 11 invited review articles are published to address current […]
Axonal dysfunction in chronic multiple sclerosis: Meltdown in the membrane.
Waxman SG.
Department of Neurology and Center for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, CT, and VA Connecticut Healthcare, West Haven, CT.
Superoxide dismutase: The cause of all amyotrophic lateral sclerosis?
Matias-Guiu J, Galan L, Garcia-Ramos R, Barcia JA.
Department of Neurology, Hospital Clinico San Carlos, Madrid, Spain.
