Animal farm: Do our four-legged friends hold the answer to inflammatory bowel disease?
Koloski NA, Brett L.
Department of Gastroenterology, Royal Brisbane & Women\’s Hospital, Herston Queensland, Australia.
High-throughput amplicon scanning of the TP53 gene in breast cancer using high-resolution fluorescent melting curve analyses and automatic mutation calling.
Identifying mutations in the TP53 gene is important for cancer prognosis, predicting response to therapy, and determining genetic risk. We have developed a high-throughput scanning assay with automatic calling to detect TP53 mutations […]
Large scale DNA sequencing: new challenges emerge-the 2007 Human Genome Variation Society scientific meeting.
The annual scientific meeting of the Human Genome Variation Society (HGVS) was held on 23 October 2007, in San Diego, CA. The major theme of this meeting was \”New DNA Sequencing Technologies & Human Genome Variation.\” A series of […]
Identification and characterization of the unique guanine nucleotide exchange factor, SmgGDS, in vascular smooth muscle cells.
The guanine nucleotide exchange factor (GEF), SmgGDS, promotes nucleotide exchange by several GTPases in both the Ras and Rho families, especially by RhoA. Because RhoA plays an important role in regulating the contraction of vascular smooth muscle […]
Disordered eating and substance use in high-school students: Results from the Youth Risk Behavior Surveillance System.
OBJECTIVE:: To examine the association between disordered eating (fasting, diet product use, and vomiting or laxative use) and use of 10 substances (cigarettes, alcohol, marijuana, cocaine, inhalants, heroin, methamphetamines, ecstasy, steroids, and hallucinogens) in a nationally representative […]
Expression and activity of P-glycoprotein (MDR1/ABCB1) in peripheral blood mononuclear cells from patients with anorexia nervosa compared with healthy controls.
OBJECTIVE:: Pharmacotherapeutic strategies for treatment of anorexia nervosa (AN) are characterized by limited success. Some drugs used (antipsychotics, selective serotonin reuptake inhibitors) are transported by P-glycoprotein (P-gp), a transporter with major impact on […]
Anorexia nervosa: Selective processing of food-related word and pictorial stimuli in recognition and free recall tests.
OBJECTIVE:: Maladaptive processing of food cues is considered pivotal in the psychopathology of anorexia nervosa. However, the influence of hunger and differences in processing because of the type of stimuli remain largely unclear. METHOD:: Memory bias for […]
Importance of autophosphorylation at Ser186 in the A-loop of salt inducible kinase 1 for its sustained kinase activity.
Autophosphorylation is an important mechanism by which protein kinases regulate their own biological activities. Salt inducible kinase 1 (SIK1) is a regulator in the feedback cascades of cAMP-mediated gene expression, while its kinase domain also […]
Dialectical behavior therapy for clients with binge-eating disorder or bulimia nervosa and borderline personality disorder.
OBJECTIVE:: This treatment development study provides summary data for standard Dialectical Behavior Therapy (DBT) with minimal adaptation for 8 women with binge-eating disorder (BED) (5) or bulimia nervosa (BN) (3) and Borderline Personality Disorder (BPD). METHOD:: DBT involved […]
CBF/NF-Y controls endoplasmic reticulum stress induced transcription through recruitment of both ATF6(N) and TBP.
Previously the analysis of promoters regulated by endoplasmic reticulum (ER) stress identified a composite promoter element, ERSE that interacts with both CBF/NF-Y (CBF) and ATF6(N) transcription factors. This prompted us to investigate the underlying mechanism by which CBF, a […]
