Covalent Linkage Mediates Communication between ACP and TE Domains in Modular Polyketide Synthases.
Covalent Linkage Mediates Communication between ACP and TE Domains in Modular Polyketide Synthases.
Polyketide natural products such as erythromycin A and epothilone are assembled on multienzyme polyketide synthases (PKSs), which consist of modular sets of protein domains. Within these type I systems, the fidelity of biosynthesis depends on the programmed interaction among the […]