Total Synthesis of (+)-Neopeltolide by a Prins Macrocyclization.
Woo SK, Kwon MS, Lee E.
Department of Chemistry, College of Natural Sciences, Seoul National University, Seoul 151-747, Korea, Fax: (+82) 2-889-1568.
Synthesis of Fluorinated Dienes by Palladium-Catalyzed Coupling Reactions.
The synthesis of partly fluorinated 1,3- and 1,4-dienes by palladium-catalyzed coupling makes these compounds available on the laboratory scale. Several catalyst systems were tested to maximize the yields and minimize the by-products. The molecular structures of 1,1,2,4,4-pentafluorobutadiene, chloro(N,N\’-tetramethylethylenediamine)(trifluorovinyl)zinc, PCy(2)R, and P(O)Cy(2)R (Cy=cyclohexyl, R=2-(1-naphthyl)phenyl) were elucidated […]
Latest Developments in the Catalytic Application of Nanoscaled Neutral Group 8-10 Metals.
In the last few decades, the synthesis and catalytic application of nanoscaled particles prepared from Group 8-10 (formerly Group VIIIB) elements have been widely explored and have achieved promising results. The innovative use of these nanoparticle catalysts may provide new opportunities […]
Spatial patterning of cholinergic amacrine cells in the mouse retina.
Mosaic of cholinergic amacrine cells (green, labeled for choline acetyltransferase) in the ganglion cell layer of the mouse retina. The somal patterning of the mosaic is degraded due to the presence of blood vessels (white, labeled for PNA) and fascicles of optic axon […]
Protective role of 1alpha, 25-dihydroxyvitamin D(3) against oxidative stress in nonmalignant human prostate epithelial cells.
Overproduction of reactive oxygen species (ROS), through either endogenous or exogenous sources, could induce DNA damage, and accumulation of DNA damage might lead to multistep carcinogenesis. The antioxidative effects of vitamin D have been suggested by epidemiological and […]
Mouse mammary tumor virus-like env sequences in human breast cancer.
Mouse mammary tumor virus (MMTV) has long been known as a causal agent of breast cancer in mice. To date, varied MMTV-like envelope gene (env) sequences have been identified in up to 74% of human breast cancers. However, the role and origin of […]
Risk factors for invasive squamous cell carcinoma of the vulva and vagina-Population-based case-control study in Denmark.
The etiology of vulvar and vaginal squamous cell carcinoma (VV-SCC) has received little attention. A total of 182 women with invasive VV-SCC (116 with VV-SCC(vulva), 66 with VV-SCC(vagina)), 164 uterine corpus cancer controls and 518 population controls […]
Production and characterization of pharmacologically active recombinant human phosphodiesterase 4B in Dictyostelium discoideum.
Phosphodiesterase 4B (PDE4B) is an important therapeutic target for asthma and chronic obstructive pulmonary disease. To identify PDE4 subtype-specific compounds using high-throughput assays, full-length recombinant PDE4 proteins are needed in bulk quantity. In the present study, full-length human PDE4B2 was […]
Effect of p53 codon 72 genotype on breast cancer survival depends on p53 gene status.
In vitro studies suggest that p53 codon 72 genotype alters the apoptotic capacity of p53 protein, with the 72 arginine (R) form of wild-type p53 harboring a greater apoptosis-inducing potential than the 72 proline (P) variant. The aim […]
Method for tracking nanogel particles in vivo and in vitro.
Hydrogels made of N-isopropylacrylamide (NIPA) can be synthesized in the form of highly monodispersed nanoparticles. After synthesis, NIPA hydrogel nanoparticles (nanogels) can be labeled by Alexa Fluor(R) 488 carboxylic acid, 2,3,5,6-tetrafluorophenyl ester through amine-terminated functional groups. This choice of dye is complementary to […]
