Medical Library

Automated Solid-Phase Synthesis of Protected Oligosaccharides Containing beta-Mannosidic Linkages.
For automated oligosaccharide synthesis to impact glycobiology, synthetic access to most carbohydrates has to become efficient and routine. Methods to install \”difficult\” glycosidic linkages have to be established and incorporated into the overall synthetic concept. Described here is the first automated solid-phase synthesis of […]

Genetic caste determination in termites: out of the shade but not from Mars.
Several ant species are known with genetic effects on caste determination but, for termites, the role of environment has been assumed to be omnipotent. Now Hayashi et al. report that commitment to the nymph and worker pathways in Reticulitermes speratus […]

Gold-Nanorod-Based Sensing of Sequence Specific HIV-1 Virus DNA by Using Hyper-Rayleigh Scattering Spectroscopy.
Infectious diseases caused by the human immunodeficiency virus (HIV) remain the leading killers of human beings worldwide, and function to destabilize societies in Africa, Asia, and the Middle East. Driven by the need to detect the presence of HIV viral […]

Multicellular behavior in bacteria: communication, cooperation, competition and cheating.
The sociobiology of bacteria, largely unappreciated and ignored by the microbiology research community two decades ago is now a major research area, catalyzed to a significant degree by studies of communication and cooperative behavior among the myxobacteria and in quorum sensing (QS) and biofilm […]

Multifunctional Fourfold Interpenetrating Diamondoid Network: Gas Separation and Fabrication of Palladium Nanoparticles.
A fourfold interpenetrating diamondoid network, [{[Ni(cyclam)](2)(mtb)}(n)]8n H(2)O4n DMF (1) (MTB=methanetetrabenzoate, DMF=dimethylformamide), has been assembled from [Ni(cyclam)][ClO(4)](2) (cyclam=1,4,8,11-tetraazacyclotetradecane) and methanetetrabenzoic acid (H(4)MTB) in DMF/H(2)O (7:3, v/v) in the presence of triethylamine (TEA). Despite the high-fold interpenetration, 1 generates 1D channels that are […]

Wrestling off RAD51: a novel role for RecQ helicases.
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks and damaged replication forks. However, inappropriate or aberrant HR can also result in genome rearrangements. The maintenance of cell viability is, therefore, a careful balancing act between the benefits of HR […]

Stepwise Oxidation of the Stannole Dianion.
Tin oxidation of stannole dianion 1 with 1.3 equivalents of oxygen gave terstannole-1,3-dianion 3. The non-aromatic nature of 3 was confirmed by X-ray crystallographic analysis. Treatment of 1 with 1,2-dibromoethane (3 equiv) gave poly(1,1-stannole) 4, the formation of which was proven by reduction of 4 with lithium […]

The Mystery of Perpendicular Fivefold Axes and the Fourth Dimension in Intermetallic Structures.
The structures of eight related known intermetallic structure types are the impetus to this paper: Li(21)Si(5), Mg(44)Rh(7), Zn(13)(Fe,Ni)(2), Mg(6)Pd, Na(6)Tl, Zn(91)Ir(11), Li(13)Na(29)Ba(19), and Al(69)Ta(39). All belong to the F4 3m space group, have roughly 400 atoms in their cubic unit […]

Exploiting Threefold Symmetry in Asymmetric Catalysis: The Case of Tris(oxazolinyl)ethanes (\”Trisox\”).
Rotational molecular symmetry, modularity and other aspects of ligand design have played a role in the development of a new class of stereodirecting ligands. The use of highly symmetrical, stereodirecting ligands may reduce the number of transition states and diastereomeric reaction intermediates […]

SCANNING: Probe Microscopy.
Weeks BL.