Challenges in implementing CD4 testing in resource-limited settings.
The scale-up of HIV antiretroviral therapy in recent years has led to a rapid increase in CD4 and CD4% count capacity to meet the diagnostic needs of staging and monitoring disease progression and treatment efficacy in adults and infants. The speed of implementation of this […]
Comments on \”Effects of a 2450 MHz high-frequency electromagnetic field with a wide range of SARs on the induction of heat-shock proteins in A172 cells\” by Wang et al. (Bioelectromagnetics 27: 479-486, 2006).
Lerchl A.
Professor of Biology, School of Engineering and Science, Jacobs University Bremen, Germany.
A functional polymorphism, rs6280, in DRD3 is significantly associated with nicotine dependence in European-American smokers.
Nicotine enhances reward functions in the mesocorticolimbic dopamine system in general and the nucleus accumbens in particular. The genes encoding dopamine receptors are thus plausible candidates for involvement in nicotine dependence (ND). We investigated 13 single nucleotide polymorphisms […]
Comments on \”Novelty seeking and the dopamine D4 receptor gene (DRD4) revisited in Asians: Haplotype characterization and relevance of the 2-repeat allele\” by C. Reist et al. Am J Med Genet B Neuropsychiatr Genet 2007;144(4):453-457.
Lee HJ.
Department of Psychiatry, Division of Brain Korea 21 Biomedical Science, Korea University College of Medicine, Seoul, […]
Curcumin downregulates H19 gene transcription in tumor cells.
Curcumin (diferuloymethane), a natural compound used in traditional medicine, exerts an antiproliferative effect on various tumor cell lines by an incompletely understood mechanism. It has been shown that low doses of curcumin downregulate DNA topoisomerase II alpha (TOP2A) which is upregulated in many malignances. The […]
Estimation of the multiple testing burden for genomewide association studies of nearly all common variants.
Genomewide association studies are an exciting strategy in genetics, recently becoming feasible and harvesting many novel genes linked to multiple phenotypes. Determining the significance of results in the face of testing a genomewide set of multiple hypotheses, most […]
Simple association analysis combining data from trios/sibships and unrelated controls.
We consider genetic association analysis that combines data from case-parent trios/sibships and unrelated controls. A general and simple methodology is proposed, using a weighted least-squares approach to combine separate information from the case-parent/case-sibling analysis and the case-unrelated control analysis. The new proposal improves […]
Osteoclast inhibitory peptide-1 (OIP-1) inhibits measles virus nucleocapsid protein stimulated osteoclast formation/activity.
Paget\’s disease (PD) of bone is characterized by increased activity of large abnormal osteoclasts (OCLs) which contain paramyxoviral nuclear and cytoplasmic inclusions. MVNP gene expression has been shown to induce pagetic phenotype in OCLs. We previously characterized the osteoclast inhibitory peptide-1 […]
Stability of Anion Binding with Monomers of a Cationic Surfactant.
Jakubowska A.
Department of Physical Chemistry, Adam Mickiewicz University, 6, Grunwaldzka Str., 60780 Poznań, Poland, Fax: (+48) (61) 8291505.
Fe(1-y)O Nanoparticles: Organometallic Synthesis and Magnetic Properties.
Non-stoichiometric wüstite particles (Fe(1-) (y)O) are synthesized using the controlled room-temperature hydrolysis of the organometallic precursor {Fe[N(SiMe(3))(2)](2)}. Particles stabilized by hexadecylamine with a diameter of ~5 nm are obtained. For such small nanoparticles, a distorted crystallographic structure is evidenced by wide-angle X-ray scattering at room temperature […]
