Synthesis and structure-activity relationship study of monotesone-A, an antifungal component of Mono
Synthesis and structure-activity relationship study of monotesone-A, an antifungal component of Monotes engleri.
The synthesis of (+/-)-monotesone-A, an antifungal component of Monotes engleri, as well as its four structural analogues were accomplished starting from the corresponding MOM-protected phloracetophenone and benzaldehyde derivatives. Antifungal activities of the five flavanone derivatives were studied against Candida albicans (14053 and ATCC 10231), Candida inconspicua, Candida dubliniensis and Candida krusei.
Kenéz A, Lestár Z, Lenkey B, Antus S.
Department of Organic Chemistry, University of Debrecen, Hungary.